Mechanical Measurements of Cells Using AFM: 3D or 2D Physics?

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

3D Modeling from AFM Measurements

There exist many techniques for the measurement of micro and nano surfaces and also several conventional ways to represent the resulting data, such as pseudo color or isometric 3D. This paper addresses the problem of building complete 3D micro-object models from measurements in the submicrometric range. More specifically, it considers measurements provided by an atomic-force microscope (AFM) an...

متن کامل

3D force and displacement sensor for SFA and AFM measurements.

A new device has been designed, and a prototype built and tested, that can simultaneously measure the displacements and/or the components of a force in three orthogonal directions. The "3D sensor" consists of four or eight strain gauges attached to the four arms of a single cross-shaped force-measuring cantilever spring. Finite element modeling (FEM) was performed to optimize the design configu...

متن کامل

Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D.

Alternative models such as three-dimensional (3D) cell cultures represent a distinct milestone towards capturing the realities of cancer biology in vitro and reduce animal experimentation in the preclinical stage of drug discovery. Significant work remains to be done to understand how substrates used in in vitro alternatives influence cancer cells phenotype and drug efficacy responses, so that ...

متن کامل

Physics-based Tracking of 3D Objects in 2D Image Sequences

We present a new technique for tracking 3D objects in 2D image sequences. We assume that objects are constructed from a class of volumetric part primitives. The models are initially recovered using a qualitative shape recovery process. We subsequently track the objects using local forces computed from image potentials. Therefore, we avoid the expensive computation of image features. By integrat...

متن کامل

Probing mechanical properties of living cells with AFM

Mechanical properties of cells play a critical role in many essential biological functions including migration, contraction, differentiation and gene expression. Moreover, cells feel and actively respond to adhesive forces and deformations exerted by the adjacent cells and the extracellular matrix. The cell mechanical behavior is increasingly recognized as a key determinant of the normal cell f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Bioengineering and Biotechnology

سال: 2020

ISSN: 2296-4185

DOI: 10.3389/fbioe.2020.605153